Cala Sisine is generally safe for swimming, offering a sheltered cove with typically calm conditions. The beach features a mix of pebbles and some sand, with a gradual entry into clear turquoise water. The cove's protected position minimizes strong currents, though it can be slightly more exposed than smaller neighboring coves. Water shoes are recommended due to the pebbly seabed. The wider beach compared to other Orosei coves means more space to spread out. Always check weather conditions before visiting, as the relative openness means wave conditions can vary. Overall, it's suitable for confident swimmers and families with older children.

The best time to visit Cala Sisine is during June or September when you'll enjoy excellent weather with fewer crowds than July and August. The cove receives good sunlight throughout the day, making it ideal for sunbathing. Early morning or late afternoon visits offer the most peaceful experience and better lighting for photography. The beach's larger size means it handles crowds better than smaller coves, but peak August can still feel busy. If planning to hike in, avoid the hottest midday hours and summer heat; early morning starts are essential. Spring and early autumn offer pleasant temperatures with a wilder, more remote atmosphere.

Cala Sisine can be reached by boat or via a challenging hiking trail. Boats depart regularly from Cala Gonone, Santa Maria Navarrese, and other ports during summer months, with the journey offering beautiful coastal views. The hiking route from the Altopiano del Golgo is demanding, taking approximately 2-3 hours each way over rough, steep terrain. This trail requires good fitness, proper hiking boots, navigation skills, and plenty of water. Another approach follows the Codula di Sisine gorge, equally challenging. Most visitors opt for boat access, which is more comfortable and accessible, while the hike appeals to those seeking adventure and solitude.

Cala Sisine is undeveloped with no permanent facilities, restaurants, or shops on the beach. Visitors must bring all necessary supplies including food, water, sun protection, and shade equipment. There are no toilets, showers, or changing facilities. During peak summer season, occasional vendors may arrive by boat selling drinks or snacks, but this cannot be relied upon. It's essential to pack out all rubbish to preserve the natural environment. The nearest accommodations and dining are in Baunei, Santa Maria Navarrese, or other coastal towns. The lack of development maintains the beach's wild, unspoiled character but requires self-sufficiency.

Cala Sisine stands out as one of the wider, more spacious coves along the Gulf of Orosei, offering more room than the smaller, more enclosed neighboring beaches. A distinctive feature is the seasonal freshwater stream that flows onto the beach, creating a small green oasis of oleander and vegetation. The beach combines pebbles with some sandy areas, providing variety in texture. Its slightly more open position and larger size give it a different character—less intimate than tiny coves but with a wild, expansive feel. The dramatic Codula di Sisine gorge backdrop adds to its scenic appeal, creating a memorable natural amphitheater setting.